GLP Medication UK is a plain-English map of the four GLP-1 medicines UK patients most often ask about: the Mounjaro and Wegovy injections, the Wegovy pill and Foundayo. It explains what each one is and how they differ. It does not tell you which one to take.
One guide per medicine, then the comparison
Each medicine has its own page on what it is, how it is taken, the main trial results, safety, and where UK licensing and NHS access stand. The comparison then puts all four on the same measures, and the FAQ and articles pick up questions that cut across them.
- The overview: how GLP-1 and GIP medicines work, and where each of the four stands in the UK.
- Mounjaro (tirzepatide): the once-weekly dual GIP/GLP-1 injection.
- Wegovy (semaglutide): the once-weekly pen and its dose ladder to 2.4mg.
- The Wegovy pill: oral semaglutide 25mg, the UK's first GLP-1 weight-loss tablet.
- Foundayo (orforglipron): the small-molecule GLP-1 pill the MHRA authorised in August 2026.
- The comparison, the FAQ and the articles.
Why the comparison names no winner
There is no head-to-head trial of all four, and results from separate trials cannot fairly be ranked against each other, so a league table would claim more than the evidence supports. The comparison sets out molecule, route, how often each is taken, UK and US licence status and side effects, and leaves the choice with a prescriber who knows your history.
Where the information comes from
Clinical statements come from each medicine's UK Summary of Product Characteristics and patient information leaflet (published on the electronic Medicines Compendium), the MHRA, the NHS, NICE and the published trial papers. The main pages list their references, and every guide and article shows the date it was published, reviewed or last updated.
No prices, no sellers, no manufacturer ties
The site is written by the GLP Medication UK editorial team and has no connection with Eli Lilly and Company, Novo Nordisk or any other pharmaceutical manufacturer. It carries no prices, does not sell, supply, prescribe or dispense medicines, and does not link to anyone who does. Manufacturer and regulator pages appear only as sources for label information.
Before you act on anything here
Nothing here is medical advice or an encouragement to use any medicine. All four medicines are prescription-only in the UK, and whether any of them is suitable for you is a decision for a qualified prescriber after a consultation. If you have side effects from any medicine, report them through the MHRA Yellow Card scheme and speak to your GP or pharmacist.